Haworth, Brian MeetSlavicGirls-konto T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological goals and you will pharmacology regarding curcumin
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the biggest element of brand new purple dye regarding turmeric, a keen Indian liven that is taken from this new rhizome of your own exotic plant Curcuma longa, and therefore is one of the Zingiberaceae family unit members. Within this part, we discuss the pharmacological circumstances regarding curcumin and you may speak about the latest molecular basics for these things. I after that opinion the fresh new proven and potential systematic spends out-of curcumin. Curcumin is famous usually because a restorative agent, but their process away from action is outlined. The newest pharmacological effects of curcumin seem to be the result of a good synergism from systems out of poor biochemical interactions with several biological needs within the interrelated signaling pathways. These types of targets are minerals eg cyclooxygenase, lipoxygenase and you will proteins kinases, and you will transcription things particularly NF-?B, STAT and you may Nrf2. Modulation of them particles impacts downstream affectors that make the antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you may antimicrobial facts out of curcumin. Such outcomes was indeed examined inside clinical trials out of curcumin getting pain and you will inflammatory disorder, malignant tumors, Alzheimer condition, aerobic ailment, and you can all forms of diabetes. The fresh products have tried varying doses off curcuminwith some other frequencies and you can period, into the standard end you to large amounts of curcumin within number of grams have to see healing effects. Find out more
Curcumin: Synthesis, Growing Role when you look at the Problems Management and you may Fitness Effects
Book Chapter Samples of bush-derived pharmaceuticals which have end up being the attention out-of carried on and you will great research and you can innovation desire has, up to now, become quite scarce. Immediately following years, the last 2 decades have been characterized by a good 100-bend boost in the amount of scientific content composed per year one are regarding benefit towards access to curcumin from inside the biomedicine. Read more
Build, synthesis and you can physiological factors off curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences and might possess therapeutic apps in lot of state claims, because talked about in detail in the earlier part. not, the possibility health-related efficacy off curcumin is restricted by the its physicochemical characteristics from worst drinking water solubility and you can instability, and that produce reduced bioavailability. Prodrugs from curcumin bring a means to improve of one’s biopharmaceutical and you may pharmacokinetic features, and may also ensure it is exploitation of your pharmacological ramifications of curcumin. Inside section, we earliest opinion the newest physicochemical and you can pharmacokinetics out-of curcumin. We after that determine the design of curcumin prodrugs having increased drinking water solubility and you will improved chemicals balance which are often translated back again to 100 % free curcumin through to bioactivation when you look at the vivo. We stress current triumph here, which have a focus on the framework, synthesis and you will assessment out-of prodrugs according to promoieties also proteins, efas, nucleic acids, dicarboxylic acids, and you will polymeric material such hyaluronic acid and you can polyethylene glycol. So it section has the cause for optimisation of physicochemical and you can biopharmaceutical characteristics as well as the physical affairs out-of curcumin prodrugs, on the goal having fun with of them curcumin types within the logical programs. Read more